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Corrales et al

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The activation of these events leads to increased vasoconstriction and atherosclerosis, ultimately promoting a pro-thrombotic state ( 2 ), and down regulation of endothelioum-dependent hyperpolarization (EDH) and factors that cause contraction such as thromboxane A 2 (TxA 2 ) and upregulation of endothelin-1 (ET-1)